Specific Translational Genetics and Genomics Unit
Discussion 1: Elisa
I chose a college farrier science lab. A farrier is someone who specializes in equine hoof care. A farrier lab is where students learn blacksmithing skills and apply those skills to the anatomy and physiology of the horse in terms of hoof care. I took a farrier class at a college years ago that was well run. At the time I had not considered that it was a legitimate science lab.
A farrier lab is equipped with forges, anvils, hammers, hoof stands, propane, natural gas, computers, and numerous specialized hand tools for working on the horse’s hoof (The Farrier Guide, 2021). A farrier lab needs to be designed and managed in a way that it is safe for multiple horses to be present at one time for farrier work. This type of lab would be considered academic and for profit. Students pay tuition to attend school in the lab and earn a certificate and credit towards an Animal Science degree.
A lab manager in a farrier lab has several responsibilities. The lab manager must maintain an inventory of equipment and handle any broken or damaged tools. A lab manager must ensure that everything is properly stowed and handled for the safety of the students and for the horses. A lab manager must also keep a schedule of students, horses, and handle issues where lab work was not able to be completed due to complications of behavior or health of the horse.
REFERENCES
Farrier science certificate. Farrier Science. (n.d.). Retrieved December 2, 2021, from https://www.oldscollege.ca/programs/equine/farrier-science/index.html.
Farrier Tools Guide: Learn what the most common tools do and when they’re used. The Farrier Guide. (2021). Retrieved December 2, 2021, from https://www.thefarrierguide.com/2014/01/farrier-tools-guide-learn-what-most.html.
Response 1…
Discussion 2: Emily
(a)
Specific Translational Genetics and Genomics Unit
Category: Research & Clinical
The Translational Genetics and Genomics Unit (TGGU) is under the category of research because they conduct research using genetic and bioinformatic approaches to advance scientific knowledge on rheumatic disease pathophysiology and inflammatory biology in hopes to find therapeutic targets (NIH). TGGU is also a clinical lab because they also conduct clinical studies through selecting individuals and families based on monogenic inflammatory diseases and clinical history (NIH).
(b)
The National Institute of Arthritis and Musculoskeletal and Skin Diseases is a medical research organization because this unit is seeking to understand the mechanisms of disease-associated genetic variants that participate in disease pathophysiology and find therapeutic techniques to improve the quality of lives affected by inflammatory diseases (NIH).
(c)
Some of the recent publications from the National Institute of Arthritis and Musculoskeletal and Skin Diseases Laboratory of Structural Biology Research which I am interested in is the “Genome-wide association study identifies variants in the MHC class I, IL10, and IL23R-IL12RB2 regions associated with Behcet’s disease” (Remmers, et al., 2010) and “Genetics, genomics, and their relevance to pathology and therapy” (Ombrello, et al., 2014). I am interested in studying genetic diseases and how specific alleles can impact specific expressions. I also think I would enjoy working in clinical labs comparing individual data and making conclusions based off the findings.
(d)
The general role of a lab manager at the National Institute of Health is to provide general administrative support to the laboratory chief, budget planning, review travel packages, and meet deadline requiring revisions (NIH).
(e)
Laboratory Manager – 303 – NIH: Office of Human Resources. https://hr.nih.gov/sites/default/files/public/documents/workforce/performance-management/pdf/303labmngr.pdf.
Ombrello, Michael J., et al. “Genetics, Genomics, and Their Relevance to Pathology and Therapy.” Best Practice & Research Clinical Rheumatology, vol. 28, no. 2, 2014, pp. 175–189., https://doi.org/10.1016/j.berh.2014.05.001.
Remmers, Elaine F, et al. “Genome-Wide Association Study Identifies Variants in the MHC Class I, IL10, and IL23R-IL12RB2 Regions Associated with Behçet’s Disease.” Nature Genetics, vol. 42, no. 8, 2010, pp. 698–702., https://doi.org/10.1038/ng.625.
Response 2…
