How did the World Health Organization (WHO) coordinate the accelerated clinical trial and production of bOPV?

1. In 2-3 paragraphs please explain how poliovirus is transmitted – additionally:

a. Why was a bivalent oral polio vaccine (bOPV) chosen as a key strategic tool?

b. What were the key steps in the development of bOPV?

c. Who were the key stakeholders involved in both bOPV development and implementation?

2. How did the development of the bOPV align with evolving programmatic needs? What were the vaccination tools available to the Global Polio Eradication Initiative (GPEI) prior to bOPV? Why were new strategies required for the polio

eradication program in remaining endemic countries? What was the programmatic impact of the bOPV introduction?

3. What were the key stages from a product lifecycle perspective that had to be addressed in the development of bOPV?

4. How did the World Health Organization (WHO) coordinate the accelerated clinical trial and production of bOPV? Why was India selected as the location for the clinical trial? Why was the clinical trial able to bypass phase I and II? Why and how did the WHO engage drug manufacturers and national regulatory authorities?

5. Based on what you’ve learned about reimbursement in the course how would manufacturers go about determining a fair price for the vaccines mentioned in this case? How about a COVID-19 vaccine for which the benefits of utilization outweigh the potential risks from a safety perspective? If your answers are different why are they different?

6. What can the global health community leverage from this experience that can be utilized during the current COVID-19 pandemic? Additionally, what other diseases could benefit from the lessons

learned in vaccine development from this case?

These are the 6 question this time.

I have attached the pdf which will help you to develop answers.

In addressing the questions presented, please feel free to develop and utilize diagrams to support your answers

Completed write-ups should in your own language and be approximately 8-10 pages in length, double-spaced in 12 pt font – please include your name (as well as your course collaborator if you choose to have one) in your submitted file (e.g. Amato – RGA6463 Case Study #3 Assignment.pdf)

If you have additional query do let me know. Also, do add pictures, pie chart and graph from the pdf or from elsewhere related to answer and place it at the end of answer completion.

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